Description

Predef 2X

FOR USE IN ANIMALS ONLY

CAUTION: Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian.

DESCRIPTION

Each mL of PREDEF 2X Sterile Aqueous Suspension contains 2 mg of isoflupredone acetate; also 4.5 mg sodium citrate hydrous; 120 mg polyethylene glycol 3350; 1 mg povidone; 0.201 mg myristyl-gamma-picolinium chloride added as preservative. When necessary, pH was adjusted with hydrochloric acid and/or sodium hydroxide. It is for intramuscular or intrasynovial injection in animals and is indicated in situations requiring glucocorticoid, anti-inflammatory, and/or supportive effect.

Metabolic and Hormonal Effects

PREDEF 2X, a potent corticosteroid developed in the Research Laboratories of The Upjohn Company, has greater glucocorticoid activity than an equal quantity of prednisolone.

The glucocorticoid activity of PREDEF 2X is approximately 10 times that of prednisolone, 50 times that of hydrocortisone, and 67 times that of cortisone as measured by liver glycogen deposition in rats. The gluconeogenic activity is borne out by its hyperglycemic effect in both normal and ketotic cattle.

is approximately 10 times that of prednisolone, 50 times that of hydrocortisone, and 67 times that of cortisone as measured by liver glycogen deposition in rats. The gluconeogenic activity is borne out by its hyperglycemic effect in both normal and ketotic cattle.