DEXAKEL 02

Aqueous sterile solution, contains dexamethasone phosphate eq. 2 mg dexamethasone fillers up to 1 ml. Available in bottles of 50 ml.

postpartum toxemia in sows and sheep

arthritis

tendovaginitis

periarthritis

bursitis

inflammation of muscles, tendons, bones

sprains

acute infectious diseases

allergic conditions

allergic skin lesions

stress

shock

toxemia in the last stage of pregnancy

Description for DEXAKEL 02:

I. General information
Name of the preparation: Dexakel 02 (Dexakelum 02).
1.0 cm ^{3 of the} preparation contains 2.64 mg of dexamethasone sodium phosphate (equivalent to 2 mg of dexamethasone); sodium EDTA, sodium citrate, sodium methyl parahydroxybenzoate, N-methylpyrrolidone, hydrochloric acid, water for injection.

The drug is a clear, colorless, odorless solution.
Dexacel 02 is available in dark glass bottles with a nominal volume of 50.0 cm ³ .

The drug is stored with caution (list B) at a temperature of 2 ° C to 8 ° C in dry, protected from sunlight, places inaccessible to children.
Shelf life 4 years from the date of manufacture.

II. Pharmacological properties
Dexamethasone is a synthetic analogue of the glucocorticosteroid hormone of the adrenal cortex – cortisol (hydrocortisone). It has anti-inflammatory, anti-allergic, desensitizing, immunosuppressive, anti-shock and anti-toxic effects. The mineralocorticoid effect is negligible.

Dexamethasone inhibits all phases of inflammation. It inhibits phospholipase-A2, thereby disrupting the formation of prostaglandins and leukotrienes. In addition, dexamethasone stabilizes cell membranes, lysosome membranes, reduces capillary permeability, inhibits the migration of neutrophils and macrophages into the focus of inflammation and their phagocytic activity, inhibits the proliferation of fibroblasts and the formation of collagen and cytokines. It also inhibits the synthesis and disrupts the kinetics of T-lymphocytes, reduces their cytotoxic activity.Dexamethasone has a counterinsular effect (it stimulates gluconeogenesis in the liver, reduces the permeability of membranes for glucose, and causes hyperglycemia and glucosuria).

Aqueous solutions of dexamethasone are rapidly absorbed by intramuscular or subcutaneous administration. Its maximum plasma concentrations are reached 30 minutes after administration.Dexamethasone is well distributed throughout the body. The pharmacological effect persists for 2-4 days.

Dexamethasone is metabolized in the liver, partially forming conjugates with glucuronic acid. It is excreted in the urine, in small quantities – with feces. DEXAKEL 02 DEXAKEL 02 DEXAKEL 02

III. The procedure for the use of the drug
Dexacel 02 is used for non-infectious acute inflammatory processes in the musculoskeletal system (for arthritis, periarthritis, tendovaginitis, bursitis, dislocation, myositis, bruises); acute infectious diseases (in addition to the means of etiotropic therapy); allergic conditions (asthma, allergic skin lesions, snake bites); metabolic disorders (ketosis in cattle and toxemia of pregnant women in sheep); for the artificial induction of labor in ruminants in the last stages of pregnancy; with shock and stress conditions (collapse, anaphylaxis, trauma). DEXAKEL 02 DEXAKEL 02 DEXAKEL 02